Important Information about PROTONIX
Read more below.

The proof is in the numbers. And the numbers showed that PROTONIX controlled daytime and even nighttime symptoms of erosive acid reflux disease and also healed the erosions it caused in the esophagus.

Just take a look at some results.

In a 12-month study involving patients with healed erosive acid reflux who were treated with PROTONIX 40 mg, findings showed that for one full year:

• • 93% of nights were heartburn-free¹
• • 94% of days were free from acid regurgitation²

PROTONIX does more than just relieve symptoms. Another study involved patients with active erosive acid reflux disease. Results showed:

• • 93% of the patients treated with PROTONIX 40 mg were healed after 8 weeks^2,3

But acid reflux is a recurring condition. Doctors may prescribe PROTONIX beyond 8 weeks to maintain healing and prevent a recurrence of symptoms. Individual results may vary.

Talk with your doctor about controlling erosive acid reflux disease and maintaining the healing.

¹ Richter JE, Fraga P, Mack M, et al. Prevention of erosive oesophagitis relapse with pantoprazole. Aliment Pharmacol Ther. 2004;20:567-575.

² Data on file, Wyeth Pharmaceuticals Inc.

³ PROTONIX® (pantoprazole sodium) Prescribing Information, Wyeth Pharmaceuticals Inc., Philadelphia, PA.

Important Product and Safety Information

Indications

PROTONIX is a prescription drug that is used to treat and maintain healing of erosive acid reflux disease, also known as erosive GERD (breaks in the lining of the esophagus), and relieve associated symptoms that may include frequent and persistent heartburn and stomach acid backup. Most patients heal within 8 weeks of treatment. Doctors may prescribe PROTONIX beyond 8 weeks to maintain healing or to prevent a recurrence of your symptoms. Controlled studies did not extend beyond 12 months.

Important Safety Information

In clinical trials, the most frequently reported side effects with PROTONIX Delayed-Release Tablets were headache, diarrhea, and gas. Relief of your symptoms while on PROTONIX does not exclude the possibility that serious stomach conditions are present. Patients who are allergic to any ingredient of PROTONIX should not take it.

Please see Important Prescribing Information.